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卵子质量差由什么决定?
andiaJun 23 2010, 08:41 AM
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9 v; _: ^* }+ CWhen referring to bad egg quality, how is this determined? I'm am confused about this...
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' U) P8 h3 I; j5 Q( w8 `& UIn my past few cycles, low amount of eggs retrieved but I have good fertilization, good 'looking' embryos (little fragmentation), most of my embryos make blasts and I do get pg each time. The problem is, I m/c around 8-10 weeks due to aneuploidy. Does this mean I am dealing with poor egg quality even though they look pretty when transfered and do implant? BTW, I am 39, but have been TTC since age 36.
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Thanks for your insight- 0 w1 Y: b' k$ [/ S
病人问:3 ~0 u. r# O3 _: C% i4 M9 d
医生,坏卵子是有什么决定的?我很迷茫。" l2 }0 y! O; W' Q' u; g+ Z# q$ T$ d
在我以前的几次试管中,每次取卵都少,但受精都很好,做成的胚胎看上去都很不错(很少碎片),大多数胚胎都培养成囊胚了,而且我每次都好孕了,可是都在8-10周左右流产了。这是不是说我的卵子质量都不好,尽管胚胎看上去都很好?我现在39岁,已经试孕3年了。
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Geoffrey Sher, MDJun 23 2010, 01:07 PM" B0 X0 J. `; T3 g3 R
Egg aneuploidy (an irregular number of chromosones) lies at the root of most embryo quality issues. It is a function of age and species (humans have the highest rate of aneuploidy of all mammals and the icidence increases with age). The only way to optimize egg quality is by optimizing the protocol for ovarian stimulation (individualized and customized to fit the person's profie).
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1 S* B& a5 Z! \/ v1 V' C* ]卵子非整倍性(不正常染色体数目)决定了胚胎的质量。这是一个和年纪还有物种(人类是哺乳动物中非整倍率最高的物种,而且随着年龄的增长变得更糟)。唯一的办法是采用最佳的促排方案来获取最好的卵子。6 C6 V/ W8 c+ W& _. J
I suggest you go to my blog at www.IVFauthority.com and read up on egg quality, egg/embryo aneuploidy and how selecting the ideal protocol of stimulation influences outcome as far as ehgg quality is concerned.
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Feel free to call 800-780-7437 if you would like to have a free consultation by phone, to discuss your case with me.
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7 v4 L! }1 D) d R& h2 }1 iJeffrey Fisch, MDJun 24 2010, 08:15 AM
6 ?- t# Z U' \: wSperm and eggs have work to do before they can be fertilized. sperm do their stuff inthe testicle, while eggs do it when you ovulate that specific egg. If the egg divides its chromosomes incorrectly, the egg will be abnormal and will not be able to make a normal baby. It can in some cases make Down's or something that ends in an early miscarriage. Even perfect looking blastocysts can be abnormal.
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" H: G9 g' @* [0 j5 s* l' B/ {' uSince egg quality in a given cycle is not determined until ovulation, there is a chance that you will make a good egg next cycle. We also think that the specific stimulation protocol can have an influence on whether the egg will do its stuff correctly. Our protocols are designed to optimize the chance of making a good egg. If you do, it will only take one to make a baby.
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/ b. `4 l9 }+ L( X6 v( w# Q4 GIf you set up a free consult with me, I would be happy to review your case with yo in more detail.
2 ?. k/ A. ~* j; m另一医生答:
% l5 O8 a/ |; @ ?2 |/ i受精前精子和卵子都在睾丸和卵巢里经过一段时间的培养。如果卵子在培养过程中分裂出不正常的染色体,这个卵子就不正常,配出的胚胎就不能发育成正常的宝宝。这种胚胎有时会生成唐氏宝宝,或者妊娠早期就流产了。甚至看上去质量很好的胚胎也可能是染色体不正常的。1 e7 O8 S& a( c, K+ z5 m$ g
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每一个周期中卵子的质量在排卵前是还没定的,所以还有机会在下一个周期培养出质量好的卵子。我们认为某种促排方案会对卵子有有利的影响使其能分裂出正常的染色体。我们的促排方案就是设计来达到这个目的。 |
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