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Beer 中心转抄来的关于丈夫DQ alpha 201的资料0 } p: h# o7 i0 I; P+ f
"A. DQ Alpha; }3 b- U: u4 y+ O+ f( o, A9 s# H P, Z
This test measures whether the DNA of the couple is too closely matched. These tests give you
! W4 A( S6 z$ u" ?2 l) w" c. Lback two numbers for both members of the couple. In a normal pregnancy the father's DNA in
8 R* ^" H) ~' k( othe baby tells the mother's body to set up a protective reaction around the developing embryo. If
. j' f& P6 J$ U6 {0 m8 `- Nthe father's DNA is too closely matched to the mother's, there is a good chance that the embryo; _" g N! n. C
created by them is unable to differentiate itself from the mother's body. The mother's body then; z. T4 j( ]+ J3 L2 B
rejects the embryo because it cannot identify the embryo as a baby.
* ?9 ?% m8 n/ @" l: qThere are two different tests for the DQ, the Alpha and the Beta test. Most patients are only
6 R" X: p% P! E- l* O" M' Qtested for the Alpha. The mother-to-be and the father-to-be get back two numbers (1.1, 1.2, 1.3,
% D8 m# G S" a% }! g- R2 @2 U1.4, 2, 3 or 4) one each from each of their respective parents (the baby-to-be's grandparents).! ?( r c! f& m4 o5 |9 w
Although there are breakdowns of the 2's, 3's and 4's, many people find that only the 1's are
2 H' q. I! L- q; m* S& Vsignificant, so they break those down to one more decimal. If both the mother-to-be's and the* P/ s7 {: D8 \
father-to-be's DQ Alpha come back with a 4 DQ Alpha or the father-to-be's DQ Alpha comes
( ^4 {$ I7 J W3 o$ {/ dback with a 2, a DQ Beta test is run. A DQ Alpha 2 translates into a DQ Alpha 201. The DQ" {* p5 @- N( E" Z1 e, D
molecule also has a beta chain, and when the DQ Beta is 201, then this sperm will only produce, g/ j6 P" `( @0 D
a placenta, and not a baby. 89% of the people who test APA positive either have DQ Alpha 4 or; @0 z* {8 T$ U! J) h3 u
closely matched DQ Alphas between partners. DQ Alpha compatibility is seen between mother
: C+ s' m8 k+ E0 a2 h5 Wand pregnancies that failed (through IVF failure or recurrent pregnancy loss). DQ incompatibility% x0 l! H; t, Q/ X
between mother and baby was far more common in women successfully delivering babies.
c; F6 v4 d6 `7 ~: K0 A& {DQ 201: If the father-to-be has a 2 in his DQ Alpha, 2% of the time a DQ Beta will show that it# m! T5 c5 {) I2 C) n, f
is also a DQ 201. Since the DQ 201 father-to-be has two DQ numbers, if only one of his
8 q- G& Z, _& u0 nnumbers is the DQ 201, he has a 50/50 chance of producing an embryo that is DQ 201. If both of! Q: x8 o* C( l2 B" b0 N
his numbers, both Alpha and Beta come back as 201, he has a 100% chance that all of his5 O/ B' ]/ Z1 L4 v H2 f* [ r
embryos will become blighted ova. The cure for this, when only one of his numbers is 201, is to
- A: f9 T9 G6 b4 g+ L1 g. c2 f! Lput back more embryos to see if you can produce an embryo that is not DQ 201. If he has both, E+ e5 ~2 _# O; r2 t% C
numbers come back as a 201, the only option is donor sperm. 100% of DQ 201 embryos become
1 c# i' @$ _0 Iblighted ova." |
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发表于 2011-5-14 18:07:00
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