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美国生殖专家与病人的问答

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发表于 2011-10-22 13:05:03 | 只看该作者
楼上的姐妹,我做了两次IVF,失败后医生就在给我做抗体检查了,你千万不要忽略这个问题,要是抗体有问题,再做也是白搭的,成功不了。我是仔细把前面二十几页全部看完了,很佩服nycersident,她一直在给其他的朋友提供专业的帮助,她前面写的,有助于你理解,我是把她的文字都保存在我的文件夹里:' I( B4 a) `% `" U5 n7 u* K
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“人的免疫系统很复杂,基本上有三大细胞:NK细胞,T细胞,B细胞。NK细胞就像是地面部队,拥有强大的火力,T细胞就像是特种部队(我觉得更像指挥部),B细胞是侦查部队。
% Q$ u9 Y4 c) w
6 Y7 F5 L, X- |0 r9 qB细胞负责识别病毒细胞和自身变异细胞(如癌细胞),如果发现新的敌人,B细胞就产生抗体,相当于在那种敌细胞上插上红标签,告知别的系统这个是问题细胞。
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$ Z: Z7 Q- w# J) V" aT细胞产生辅助细胞因子TH1,TH2。TH1高就表示身体有危险,各个免疫系统进入作战状态;TH2高就表示身体没有危险,免疫进入停战状态。TH1高低和病毒细胞或变异细胞抗体的数量有关。( H! \* g4 |+ B6 L* X% }0 W  c% R4 D  z+ \

6 d- r+ E9 a. zNK细胞拥有强大的火炮,当T细胞发出攻击命令时(TH1高),NK就顺着血液流经全身,遇到问题细胞就一个个杀掉。
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% w+ |: z' F" b7 n4 p+ O* X3 g& C2 r如果有甲状腺抗体,并不意味着免疫系统已经激活(T细胞已经下达攻击命令),但是血液中有过高的NK细胞,说明已经激活,免疫系统正处于作战状态。治疗的办法是一:减少NK细胞;二:降低TH1因子。”
3 l2 F& w" ^( I$ I! ]8 ~& R4 Y7 L' W; r1 q2 s4 y% I* P; R' r& y
我的理解是:NK相当于杀手细胞,它会以为胚胎是异物,会杀死他,如果检查出这个数值太高,要降下来才行。
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; m/ H! ~# H/ T其实我都很想联系上这位nycresident, 因为我在伦敦做了两次失败后,医生说做抗体检查,我说起封闭抗体,要是阴性,要打入老公的淋巴因子,把封闭抗体转阳,我的医生一脸茫然,似乎没有很好地理解这个封闭抗体,说做针刺受精就不会存在这个问题,我很纠结,因为这个医生也是非常专业,有十几年的经验,马来人,中文都可以对话的,我从未流过产,唯一就是宫外孕切除了一侧输卵管,做了两次IVF,失败,我已经做了很多项的抗体验血,报告还没有看到,我要做封闭抗体的检查吗?请教大家!
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242#
 楼主| 发表于 2011-10-22 15:03:08 | 只看该作者

回 240楼(jing2011) 的帖子

英国和免疫有关的专家有这些/ I3 C' {+ d0 p/ |  P9 n+ j
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Dr. Masoud Afnan% H1 H9 @3 b& B$ P, _9 c' V, |
The Priory Hospital1 V5 F; W( p1 W# s  Y
Priory Road, Edgbaston + I( j9 ~0 ^" K  N- j
Birmingham ; F$ @# P! r8 s  I5 o
West Midlands, UK 5 U6 T4 ?. J& E/ L
Post code:B5 7UG
1 J7 V. I2 A: h2 K" I+ g- E% aTelephone:01214402323 6 p8 e- Y1 Q# `6 O# O# E5 g9 b
Email: MASOUD.AFNAN@bwhct.nhs.uk " z8 W: `  w* a' b# r- ^
Patient comments: “Will work with Dr Beer directly. Will write prescriptions for Dr Beer’s UK patients and order IVIG infusions.”* @6 A7 l3 s) q0 O! Z
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Dr. Paul Armstrong " z  T% K( m5 X" R0 O6 ]
Dr Paul Armstrong
  N3 j6 }; x- f, sThe Portland Hospital) N5 ~. S5 Z' b0 @" f/ C! W
205-209 Great Portland street. k7 W; X5 c/ I) G
London W1W 5AH England 7 L  E/ ?! K) O) ^4 O& y
0207-580-4400 (Speak to Paulette his secretary) 2 B* ~; b9 Z9 G) {& A3 w" R! W4 w* f3 a
0207-390-8156 (Speak to Milly his secretary)! i  L; B9 e* D1 T! c
Email: drpaul.armstrong@btconnect.com
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* v9 e* z. _& ?' T8 Y) t! gRoyal London Hospital1 o: a- d$ s; _: P2 r. A, r! v- s
Whitechapel London E1 1BB England
0 y% S  l# }2 ^% A9 C2 A. e6 [9 Mph  0207-377-7000 ex 2579# K: r; J  ]6 b! q! o/ a
Ph (Speak to Anne, his secretary) 171-377-7000 ext. 2579
) D0 y5 h- b$ |5 E% Q, x; N) F  I5 hURL: www.drpaularmstrong.co.uk
/ q. W8 l& h# Y  \  Z' wPatient comments: “Does both LIT and IVIG. LIT is done subcutaneously and intravenously. He states it is more effective and works faster this way when I asked him. He also wanted me to do the LIT just the once 3 weeks before ET, so no
* I* ~; \$ f2 _4 X) P4 I! kretesting.” “Does not do donor LIT. He only meets patients on Fridays and does LIT treatments on Tuesdays. Dr Armstrong does advocate IV LIT along with subQ.”
: h( l0 N6 b1 E( M6 r8 jAlso: “As of January 2009, apparently he will prescribe Intralipids” , D8 y6 D; v& N% I) q
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Dr Eapen! _$ n, V& T/ P: q* ?) P
Midland Fertilty Clinic, Aldridge! \' B9 ^# A8 E: p4 w6 d! Y
UK
- {  P" ?* Q& z% x$ b  iComments: “Dr Eapen, lovely man. Uses corticosteroids to modulate the immune system”
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& H* d4 {0 x1 |; M9 BDr Amin Gorgy$ G, M. _5 y6 T
The Fertility & Gynaecology Academy0 {5 y% d- T* P
57a Wimpole Street, B; D1 `, i' p3 z' q& A7 U
London W1G 8YP
( X. i6 {. u& K6 dU.K.9 ]( z3 z5 [# V6 h& v6 U
Tel: +44 (0) 20 7224 1880+ ]9 P. n4 f, T. J' H
URL: http://www.fertility-academy.co.uk/1 E. N$ C6 r5 y& H" c/ s: P* O) P
Patient comments: “He used to be a director at the London Fertility) C8 {7 q0 n. I' \
Centre and then at ARGC and has now set up his own. p8 L' v) T( a
clinic. I rang up and had a consultation (£100) with him and+ e) [6 i6 A% Z' ~0 G2 V+ V
he has agreed to prescribe all my immune meds. (ie" q1 k" y7 q$ z$ y5 \+ h  l: a6 ~, P
steroids, IVIG, gestone etc) and administer the IVIG
" s6 S  }$ U, J& iat his clinic. He was recommended by( J/ E1 }0 u, j- ]( Q( o2 b
both Dr. Beer (who he worked with at the ARGC) and one
0 g5 U- X9 I( I4 `" Oof the doctors at the LFC.”
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More patient comments: “Yes he is nice, although a little on the quiet side at first and it takes a while to get to know him.Costs- well the Chicago tests are £780 for a comprehensive panel (about the going rate for these tests) a consultation is £100 and a folllow up £70, standard IVF is £2000 + drugs and blood tests. The drugs are expensive, but you can't get away from that, Mr Gorgy will give you a prescription and I shopped around for the best price I could. There is not usually much of a waiting list. Yes, Mr Gorgy is knowledge about immune issues and certainly has got me further than anyone else so far.  One of the best things about being treated about Mr Gorgy is that compared to drs at other clinics I  have found him very accessible, you can speak to him on the phone (although sometimes you might have to chase!)”
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“As of December 2008, apparently Dr Gorgy will prescribe Intralipids”
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& j1 ^7 @, u  `* fMr. Taranissi (IVF doctor)
+ ^* f1 C3 `7 u  y  k/ S: h* ^Assisted Reproduction and Gynaecology Centre (ARGC)) Y1 T. T# g& a' |: ^
13 Upper Wimpole Street, ; b: @1 I! r, \- g* R' I6 s, x
London, W1G 6LP
" C" @! w( }9 t, u1 e+ KARGC, London, UK
  a! r! y8 s( x2 G, f* rNew patient information line Tel: 0207 935 3959
: y4 c4 P# r1 u: d& `, uTel: 020 7486 1230
# E" J6 ?7 `: I: L& u' J) @  P1 FFax: 020 7486 1232
7 l/ Q7 Z' \$ T- P6 |( }9 E% k4 p  KEmail: info@argc.co.uk
- u% n( Y; D3 n' nWebsite: www.argc.co.uk
9 _" I- o8 f0 T2 l4 {Patient comments: “Taranissi used to collaborate closely with Dr Beer when Dr Beer was in London. Uses IVIG, Enbrel and Humira. Taranissi will also verify good stim response before  moving ahead with preconception IVIG, so he often starts IVIG later& K: z9 d: O- J5 V/ k2 n+ y) D6 ~4 |4 [
in a cycle than Dr Beer does Unlike Dr Beer, Taranissi uses IVIG after ET instead of before ET to assure that the eggs quality is good beforehand.”
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7 m% C/ l5 r+ B1 |! E/ q7 f( ~Dr George Ndukwe (IVF doctor)% k$ }! X- W1 F
CARE at The Park Hospital
) h( Q; w) M' N+ T; e9 F) ?Sherwood Lodge Drive' ^6 h3 Q# h# s# p) k5 N- [( F
Arnold
  W! ^. V8 w5 G) U4 q; D7 qNottingham NG5 8RX
8 f2 q0 Y, w6 `7 CTel: +44(0)115 9671670
  S8 X& N$ M% k% o& yFax: +44(0)115 96735423 X2 [) ?8 v* g4 n
Email: George.Ndukwe@care-ivf.com
8 Z  _0 F/ s# W6 n. I$ x0 R. R: LEllie ellie.boulton@care-ivf.com (Dr Ndukwe’s assistant. She responds more promptly to emails)- D9 P& w, A. A
Website: http://www.carefertilityweb.co.uk/
2 G, T2 B. C; rDiscussion board: http://194.72.47.117/cgi-bin/ubbcgi/ultimatebb.cgi?ubb=forum;f=117 f  \5 p8 v' @+ g, V7 G: A& v5 |# }
Patient comments: “Uses IVIG and Humira. Ask to speak to Liz Carmichael who deals with all Dr. Beer patients. Only works with patients locally. Will not work with long distance patients.” “As of January 2009, apparently will prescribe Intralipids”
7 b8 e) S6 D% ]- }4 W2 j3 f& b7 x& g: T1 H- V$ {! ~
Mr Adel Shaker (IVF doctor): q# g; `# b0 O' v6 ]
Consultant Gynaecologist – Medical Director/ s% r2 @  F' q
CARE Fertility: T- q& J5 J) v+ r  s2 y
24-26 Glen Road% y+ }5 e4 D, l9 v8 E
Sheffield S7 1RA- S! n4 Y, |" ?; e  Y; t  l
Tel: +44(0)114 258 9716! d% O  C2 e+ l! T) Q
Fax: +44(0)114 255 4853$ c, T. S8 _: a9 Q- A" }7 {( D2 Y, N
General Enquiries: sheffield@carefertility.com
" x, T0 X) o& W/ ^URL: http://www.carefertility.com/loc ... age-care-fertility/8 C9 q1 Y2 R4 j6 W% `5 Z) A
Comments from website Feb 4, 2010: “We are now running the Reproductive Immunology (RI) programme. RI helps couples who have previously had recurrent IVF/ICSI treatment failures or recurrent miscarriages linked to abnormality in the woman's immune system, achieve a live birth. For an appointment please call us on 0114 258 9716.”# Y% r# ?' a) C( L2 z
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Dr. Thum M.D.* g+ h2 ~  A9 H$ A; m9 }  A
The Lister Hospital Assisted Conception Unit
: r, j- x: `) s' Z5 hChelsea Bridge Road
& I' {% ^& x8 y% D$ |8 L% b5 hLondon, SW1W 8RH
; ~8 M  Q& m3 y/ X; _9 u2 N) UTelephone: ++44 (0) 20 7730 5932# a5 W; i! N" ~2 {* l: H/ z  A
Fax: ++44 (0)20 7259 90395 ^" V$ X3 b9 ]/ h2 |! K
URL: http://www.ivf.org.uk/' \/ a+ ]" h0 R+ T. U
Patient comments: “The Lister doesn't offer IVIG either ... in fact I think Dr Shehata and the Doc at the Lister (Dr Thum) have actually published some research papers together on NK cells. They've obviously collaborated in some way, and I think they both opt for Prednisolone as treatment rather than IVIG”..” I'm not sure what the Dr will prescribe if any of my other tests come back +ve, but I think he said Heparin. I'll let you know after I get the results”# I$ |! _7 s, v! ]2 M' p
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Dr Hassan Shehata, MD  (recurrent miscarriage specialist)
* ]  y8 p7 h% |9 x: bHarley St Clinic
& S% p) |; x% D" {$ l103-105 Harley Street - Flat 3* o8 p  S) A' _7 z
London W1G 6AJ 2292: v6 P0 p- `+ o! e6 w
Tel/Fax: +44 20 8648 2990 - _' U9 U; `: }& f9 E- D
To arrange a private consultation simply call/fax Hilary Glynn 9am-5pm Mon-Fri 4 C, T5 C' Y0 y1 R
E-mail: hilary@miscarriageclinic.co.uk
4 o/ @2 _5 T4 }( O. k# pURL: http://www.miscarriageclinic.co.uk/index.html% v$ v/ R5 n- ~+ @1 t' t, n  U
Patient comments: "Doesn’t agree with LIT, IVIG but says that Dr Beer is a pioneer and inspired him to devote his time to researching immune problems and miscarriage/infertility. Big believer in prednisone"
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Dr. Siobham Quenby
' z) J$ E6 o, {/ eLiverpool Woman’s Hospital, ( U! x4 l0 C+ w  w" |
Liverpool, England 4 Y. l2 j' Q, e4 _3 w/ \
Patient comments: “She has been doing a clinical trial looking at NK Cells in the uterus with both natural m/c and IVF failure. I was part of the clinical trial and would love to chat to anyone else who has also been treated by her. Dr Quenby tells me that there are a couple of other IVF ladies that she has seen, but of course she can't disclose anything else.”
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Dr Trevor Wing
$ x, V4 S3 j5 g9 rThe Women's Natural Health Practice
: X" i0 k5 b/ ZThe Glasshouse
; U7 c2 ?8 @* Q6 p( ^River Lane, Richmond
7 A3 T8 m) t5 x: M6 }Surrey, TW10 7AG5 N7 S! D4 i* ~$ I& u
Tel: +44 (0) 845-688-5270
" P# ~* ~4 B1 I0 ]4 `1 Q+ b" M Email: enquiries@naturalgynae.com8 K  ]  m0 |2 T- X
URL: http://www.naturalgynae.com/: |8 f3 I' n  G1 J$ s
Patient comments: “I am also a patient of Trevor Wing (www.naturalgynae.com) who does the immune test through Beer Centre for his patients. He did the NK Assay, DQ Alpha last week, hopefully the results will be in by the end of this week from Beer Centre. He has already scheduled an endometrial biopsy for me on 1st Dec. before the instruction from Beer Centre. If your own local doctor is willing to help with the blood taking you could pack and Fedex them yourself. Lots of ladies in the UK have done their blood test this way. CARE Nottingham Mandy mentioned has good reputation, threfore, there is a 12-week waiting for a consultation, you also need your own doctor's referral. As Mandy said there are a few choices, it is a personal choice. I choose Trevor Wing to do the immune test for now is because he is only half hour . K( \- K0 z2 T8 @5 y5 S' L
driving away.”
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发表于 2011-11-3 14:35:40 | 只看该作者
曾人流8次, 之後沒再懷上。做試管9次,2次宮外,7次不成功。 基本的檢查都做了,正常。 第9次做試管時,子宮膜7mm。是否太薄? 醫生也懷疑是子宮膜問題。 已經吃補佳樂,還是不成功。 子宮膜有問題會影響IVF嗎? 有什麽良策良方? 謝謝。
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244#
发表于 2011-11-3 16:28:42 | 只看该作者
我也想去查是不是甲减。查这个要验什么啊
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发表于 2011-11-3 18:51:06 | 只看该作者
下午在办公室又重头看了一遍,顶一下!
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 楼主| 发表于 2011-11-3 19:37:52 | 只看该作者

回 242楼(xybbdren) 的帖子

去查免疫吧,免疫有问题,内膜也会薄。
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发表于 2011-11-4 10:23:43 | 只看该作者
[: `. ]1 w+ n) q. s' c3 @* }4 c+ u* `
楼主,我的情况是。促排前没说卵巢不好。fsh6.1   lh4.87  prl375.28  e152.09   t0.61   降调前8个卵。降调后6个打果纳芬后期加乐宝得。促了15天就取了三个卵。二个不成熟就配成了一个。在移植那天告诉我停育了。伤心啊。医生也不知怎么回事就说我卵巢功能太差了
# j; a# \* [: I7 o  搞得我一点信心都没有了。像我这样还能再促吗?我是80年的。平时月经量就很少。估计卵巢是不大好
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发表于 2011-11-4 10:26:57 | 只看该作者
楼主你好,我好像用的是长方案,就是打了一针降调针后过了十几天来月经第三天才去促排的。另外我的泌乳素是不是高了啊。医生也没给我吃药!
& [  L( {$ R4 ^( a' B     谢谢你了
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249#
发表于 2011-12-17 19:28:05 | 只看该作者

回 236楼(baobaobeibei) 的帖子

引用第236楼baobaobeibei于2011-10-12 16:35发表的 回 80楼(nycresident) 的帖子 :
1 P  c+ q" e# l. ^5 O2 F' KNycresident你好!我看到这本书背面介绍是: : J- K' E6 n' b8 g% M- t
For over 25 years...Over 7000 couples have sought my help and have achieved a success rate of more than 85% within three cycles. 6 M& X6 d  k9 [, Q+ }( I
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说实在的,对这句话不太赞同。如果生育是简单如此的问题,那就不会有那么多姐妹还在痛苦中挣扎了。3个周期就达到85%的成功率,有点过大了吧。 1 O8 e+ E. ^2 w/ Y! q
不过他树立写的很多东西很值得研究。我也买了这本书看。

" O5 |1 b# F% z我觉得这个数据是有可能的。三个周期是三个例假周期,就有三个月了。中药调理也差不多时间,也开始有效果了。
$ U8 ?- U% P7 M一般书的背面写的都是宣传资料,多数是由有权威或有名气的人写的认同的宣传类信息,可能带有夸大成份,但不是作者写的。
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250#
发表于 2012-5-30 13:00:57 | 只看该作者

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你好,我也是借卵的试管。去年做了3次,第2次成功后流产,。今年查出有甲减,但是吃药恢复到正常值,就i是还有两个抗体还是很高,我马上就要试管了,对胚胎有影响吗?我没有做过NK的检查。
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