http://www.ktl.fi/bios/know/traffic.html
1 R, u5 q k% rThis site was produced by an individual working with intracellular transport mechanisms. This page is an introduction to the types of problems a cell faces when these transport pathways are not functioning properly. General:4
0 o% r) J' x# b* n. {, ]% _$ Rhttp://shubashi.physiology.rwth-aachen.de/bs/erys/shapes/ % n# U/ o$ [4 m% j. X2 ^9 j
Here they present the results of vesicle shape calculations sorted by constraints on volume (v) and area difference (h). A well-made Java program. Very useful if you ever need to determine the shape a vesicle will take based on these parameters. Specific: 4
: F J1 N3 a4 Y( Ghttp://www.ultranet.com/%7ejkimball/BiologyPages/P/ProteinKinesis.html#rer
. z5 t3 G" U1 \6 A8 lA very comprehensive site discussing protein kinesis. Good illustrations, and several links to more related information. The author gives good credentials, and seems to be well organized. Specific (but linked to a General index): 5 : V- q8 y( u4 v
http://vl.bwh.harvard.edu/labs.shtml#membranes * G0 c0 R# S7 \: i6 \0 F& E
This site provides a list of lab exercises that pertain to investigations into Membranes, Organelles and Vesicle Trafficking. Specific: 2 # `5 J7 A1 S; X, P
http://dir.nichd.nih.gov/cbmb/pb1labob.html
! m. i" V/ X# X4 o+ N3 k9 VWeb summary of Nature, Volume 389, Pages 81-85 1997 that contains many quality animations (note: the movie player plug-in must be installed). Discusses experiments regarding the transport pathways of the Golgi apparatus. Specific: 3 6 `) `6 l* T+ J
Cell Scaffolding
+ e4 N9 g1 E$ x0 l, j( shttp://expmed.bwh.harvard.edu/
& j6 Z- v% p% d4 ~& k6 L' BThis site summarizes research on actin at the Brigham and Women's Hospital. It has lots of information and some interesting movies about cell motility and its relation to the cytoskeleton. Rank: 4.
' b% U$ e5 q$ e+ I+ `http://gened.emc.maricopa.edu/bio/bio181/BIOBK/BioBookCELL2.html 6 x, o/ P" O6 n* F: H
This is a portion of an online biology textbook. It contains very good cartoon illustrations of cellular scaffolding components and a description of their use in inter- and intracellular motility. Rank: 5. * y" P) L/ Y" N2 Q
http://dir.nichd.nih.gov/CBMB/uobf3a.mov $ l/ b/ `# `( S/ z: c
This is a movie of vesicular traffic into the Golgi, visualized with Green Fluorescent Protein. Not much information about cellular ,scaffolding, but a nice way to visualize the intracellular motion made
7 ?* Q1 Q1 O/ E; _possible by the scaffold. Rank: 2.
+ l* Q1 ]) C* c3 ^: J ]! Ehttp://www.cbc.umn.edu/~mwd/cell_www/chapter2/skeleton.html , \) G- Z- h2 @& b
This site is currently incomplete/under construction, but it has some interesting facts about centrioles and actin. Further entries regarding other components of the cytoskeleton are presumably forthcoming. No images. Rank: 2.
4 y' C2 \" e- M/ f" c) ?1 _http://web-mcb.agr.ehime-u.ac.jp/bunnshi/sec7.htm % y! {( W i/ g6 Y; U" @
This site provides an excellent summary of the unique features of cellular scaffolding in plant cells. No images. Rank: 4
# r5 |1 R2 O9 O( K1 d( ~ XMolecular Motors ' t) b0 I, E+ o+ O! p/ M" k) F
http://www.sci.sdsu.edu/movies/actin_myosin_gif.html
; F0 S2 M m @! G9 \Actin myosin crossbridge 3-D animation. The animation shows the need for one ATP to make the myosin complex "walk".
6 o! y6 M3 S) I3 lhttp://199.17.138.73/berg/ANIMTNS/kinesin.htm / @* p5 L% R4 P7 g8 O
This site has a diagram showing how kinesin pulls "things" down the microtubule away from the cell in the negative to positive direction. Also, this site contains a link to more information on dynein.
5 O9 s/ |: ^' v( e; Nhttp://mc11.mcri.ac.uk/hypertour.html & b1 H8 }! l0 Y, c
A very good site decribing the role of molecular motors. The site contains links to diagrams which further explain how molecular motors "walk" along the microtubules in order to pull chromosomes into position.
5 N; B& t7 B. D# `: R* hhttp://www.ascb.org/ascb/mbc/brochuretxt.htm
: b" B: \- ~0 {8 V0 J! D8 A" RThis site tells why molecular motors are so important to study. It also gives a detailed description of myosin versus kinesin, including various universities studying this topic. ; P- K& n" `) k! Q
http://pmi.princeton.edu/faculty/SMB.html
* n% A5 E8 a7 A5 }% }Dr. Steven M. Block discusses his research interests in molecular motors and
$ I. \ n4 n6 Ewhy he feels it is important to study them. It also gives 3 reasons why a
" \% D/ x; b4 q$ S, jmotor mechanism is difficult to construct.
) s/ I$ t. h. [' X( U8 g# dIntercellular signaling (Cell Signaling) [) |; E* m0 e( P
http://www.bio.nd.edu/biology/faculty/goetz.html 2 T. }: d |! n# F5 H/ b
A very specific website that pertains to intercellular signaling. This website was developed by one author, Dr. Frederick W. Goetz, a professor at the University of Wyoming. Dr. Goetz is studying the mechanisms and hormonal regulation of ovulation in zebrafish. More specifically he is determining the genes responsible for mutations involved in oogenisis and spermatogenisis. There are images present. (5) 3 C9 ?9 o- n5 ^. j' e0 y
http://www.ummed.edu/pub/l/ldasso/
F5 k% k3 c* YA website created by Dr. Leonardo Dasso of the University of Massachusetts Medical School. Included in this website is a specific, but brief, overview of Dr. Dasso韘 research on the function of Ca2+ and cAMP in intercellular signaling. More specifically, Dr. Dasso researched the role of Ca2+ and cAMP in increasing the beat frequency of cilia in epithelial cells. This website also has links to selected publications and other pertinent articles. (4)
7 u- N' ?" R; d) ~1 }- S0 m; ?http://cpmcnet.columbia.edu/dept/gsas/anatomy/cndb_it.html ) |2 _8 x1 m% {, j7 k8 g. P/ T
This website is a link to Dr. Richard H. Kessin of Columbia University. It can be found by double clicking Dr. Kessin韘 name in "Intercellular signaling." This is a specific website that can be a link to other articles written by this professor and other professors that deal with intercellular signaling. Dr. Kessin韘 website focuses on the evolution and mutagenisis of Dictyostelium discoidenum. Minimal pictures are present. (3) / \( p+ |5 Z& G. Q- M9 F Q3 s
Intracellular Signaling (Receptors, 2nd messengers)
+ P9 G. q. S+ |http://www.geocities.com/CollegePark/Lab/1580/cdc42.html
- |3 Z! {% s1 E+ m# p' q8 U! z% \# OThis site gives a very thorough and easy to understand view of Cdc42 (a G-protein) and its uses inside the cell. This site gave a simplified and clear presentation of the processes involving Cdc42. There are links along the way through the page to other pages that go into detail about G-proteins in general, cell cycle control, and other topics important for the understanding of the functions of Cdc42. This page also has several diagrams along with text to further the explanations of the topic, and at the bottom provides links to other material concerning cellular biology.
+ U1 i, ~& {: e* x5 j% O: nhttp://flybase.bio.indiana.edu:7088/.data/allied-data/interactive-fly/aignfam/camplern.htm
) B- ?9 h& q% h/ i8 w4 wThis page contains links to webpages that discuss G-proteins, cAMP, and other cell related chemical reactions and proteins. This page is good as a resource for intracellular communication "techniques" used by cells and gives fairly lengthy overviews of what these proteins do, although most of this site is directed at the cAMP second messenger system process. Even though it lacks any diagrams, it is still a good site for written information.
/ z" H) c1 b6 J( o! u9 X4 J h# Vwww.bio.davidson.edu/biology/courses/immunology/flash/ip3.html g, E, L. V3 _5 }+ ]) g1 P
This site is operated by a Davidson Professor (Dr. Campbell) and portrays a step by step animated visual of an IP3 signal transduction pathway. This is the only visual that this site shows, however it is very helpful in understanding a basic intracellular communication technique in a very comprehensible manner.
/ q! ^9 u8 [( t- awww.ariad.com/st_over.html
: v+ c4 }- _' O0 R: X4 \; Y* IAriad, a pharmacological research company that explores "intracellular protein interactions that make up signal transduction pathways," has established this site. The company韘 focus is the creation of small molecule drugs that inhibit signal transduction pathways. We chose this as one of our top sites for its diagrams as well as its links to more specific information about the cell proteins it researches. 4 }1 @" A" k2 i+ m. q8 C
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http://www.clarke-inst.on.ca/research/cellular_communication.html 0 h# ~1 N5 z3 h
This site reveals the mission of Dr. Jerry Warsh as he attempts to elucidate the significance of intracellular signaling disturbances in manic depressive illness (bipolar disorders). This site describes the importance of calcium levels as cell signaling devices and G-proteins as surface membrane protectors. Though lacking diagrams and specifics of their research it presents an interesting explanation into symptomatic effects of errors in intracellular signaling processes. % @% _/ k( W( ]
Protein Degradation ) O" V4 _. ~ i; K: z% s" ?
http://www.biochem.emory.edu/protdeg/lyso.html % H- V% {7 x8 [. L* {3 b
great overview of lysosomes--recent research on protein degradation accessible from here . S, B5 ]9 k6 f m# H8 Z
http://www.mblab.gla.ac.uk/dictionary/ # S9 O/ O) a- K
a great place to start a search on proteins and other topics-- provides links to tons of sites : H% q- y5 f- ?( z; x6 v
http://www.biochem.emory.edu/protdeg/home.html + b* V n" M* g
basics of protein degradation: how, why then moves into to proteolytic systems + a9 h$ Q1 P# ]
http://www.ccc.nottingham.ac.uk/~mbzmail/students/ub/ubindex.html
; S( r6 H2 a" {* h4 T% Agood 3-D's of protolytic molecules great explanation of the ubiquitin/proteasome pathway 7 W% k& y0 M, z6 c+ d" H- L$ `7 w4 ^
http://www.bwh.harvard.edu/proteins.shtml , E1 M3 F. v3 }' u
gives links to other great sites on protein degradation 6 L! l7 B- ~" l7 b5 R( x
Cell Cycle
& s4 p0 a+ j V1 G$ N- v/ }% R7 Yhttp://lausd.k12.ca.us/~kmcmahon/AP%20Bio%20Lectures?Cell%20Division/Cell%20Cycle.html
; h: ]' n! g7 M8 E/ m' S" b0 ICycle.html
, U! Q) P; U! NThis site showed the phases of the cell cycle in a flow diagram, showed cell cycle variation (interesting); it also showed the difference between external and internal regulation utilizing diagrams. This site also ! J, J% t% L: u/ k8 T
discussed cancer implications. It has both images and animation, most specifically the mitosis picture). This site was good in that it broke down information to the basics, but there was not much specific information, but more on the general sense. Rating: 4 ( X5 Z- J5 o: W% P, ^
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/cellcycle
' ~( c, {( O9 |- ?: Y3 I& [This site proved very interesting, showing the factors controlling the entrance into mitosis, further showing diagrams exhibiting this entrance. (gene --> protein --> function) It goes on to describe cancer. The only drawback was its specificity - this site was a bit too specific when wanting an overview on the cell cycle, since it concentrated more on the technical factors. Rating: 4
+ s |4 n( z8 k4 ?: k5 E; E' |http://opbs.okstate.edu/~melcher/MG/MGW1/MG1331.html , a. p) e) d/ [1 L6 S; n; j% s/ {
This site showed the unicycle/bicycle interpretations of the cell cycle, and also showed the basics of mitosis. It had nice, simple diagrams and links to other interesting sites. The animations of mitosis were pretty neat since they showed the cross over, but it was not extremely technical or too informative.
# C. R9 b3 b: ]: ARating: 3.5
/ x( H+ V5 ] L, ~9 {http://clam.rutgers.edu/~arames/CELLCYCLE.html ' Q+ Y& {, g }- J* j( V
This site showed an overview of the cell cycle, had great graphics to animation showing the transition from G1 to S to G2 to mitosis. It had great general information, but still was of a good caliber of learning, meaning that it was not too basic. It had a neat "supplementary guide" link which had a cute little quiz. Shannon and I liked this one the best. Rating: 5 : O1 o# p; g# h; ^
Virtual Biology:
/ d6 l9 a5 w1 C; Yhttp://www.bio.davidson.edu/%20%20www.seoulin.co.kr/~virbio/index.html%20%20%20www.seoulin.co.kr/~virbio/index.html . x) t4 ?( R3 X
Really cool animation on the cell cycle, as well as other cell processes and structures. Easily accessed through the Davidson bio www links page.
& s4 n" o! c7 \8 r6 k; iThe Biology Project: ^* k+ H+ w/ V5 O
http://www.bio.davidson.edu/Biology/kabernd/cb/www.biology.arizona.edu/cell_bio/tutorials/cell_cycle/cells1.html
% v# O8 s$ @/ K1 W) m* |8 m' r4 ^This site, established and updated by the University of Arizona, has a tutorial of the cell cycle, along with nice accompanying graphics. At the end of the tutorial is a challenging multiple choice quiz to test what you just learned. / V- o1 Y$ ?7 z/ U3 U4 y3 r
Cell Cycle Regulation: & \* R' G0 a" y0 U6 d$ [
http://www.geocities.com/CollegePark/Lab/1580/cycle.html * d# j4 y# I) @. B7 b
This website provides a detailed description and images concerning cell cycle control and apoptosis. The overall objective of this site is to discuss cell homeostasis. The five sections of this site are "Rb Pathway", "p53 Pathway", "Pdc42", "Apoptosis", and "integrins".
: }" \* x6 n2 M4 Q. X6 fThe Forsburg Lab Pombe Pages: 8 @! ?) t+ u( g8 X2 }
http://pingu.salk.edu/~forsburg/%20
) \" h6 V. }% X+ x. X& ~This website discusses in detail the cell cycle and fission within yeast. The site has main segments discussing cell division and DNA replication using diagrams and figures for explanation. The structure and function of chromatids are also explained. # J* {: B6 [. l, V5 k. j$ p; w# z
0 @$ c" D9 x/ J ( U h+ Y* W, W3 J
Apoptosis " j/ w( s, K! [2 }' B5 ]' k1 J
Apoptosis Interest Group a2 I, d. m$ b+ V% u! l
http://www.nih.gov/sigs/aig/index.html
( V/ O* P$ h; f7 e9 @* Explanation of apoptosis * Information on Apoptosis Interest Group * List of research groups and their work
- n( h- q0 W! L; \# K: HApoptosis Online
2 b! n* P2 o9 Z9 P; I; W: nhttp://www.apopnet.com/index.htm ( B" F) \3 |! V. j5 I) J
* Apoptosis forum for posting questions, answers, etc. * Career information * Community Center with meeting schedules and grant information * Reference library
5 [+ K% {( f9 Q8 a! jJ. Kimball's Apoptosis Page
, g, Z' ~, m+ D8 thttp://www.ultranet.com/~jkimball/BiologyPages/A/Apoptosis.html - D5 z% W& u4 s6 V2 e" y
* Outline of cell death * Explanation of why cells commit suicide * In-depth diagrams * Mechanisms of apoptosis * The role of apoptosis in cancer, AIDS, and organ transplants. This site has an easy to follow outline, good explanations, and also relates apoptosis to diseases, such as cancer and AIDS.
' x6 e N8 G& T7 E$ [0 b, @# wUniversity of Maryland 7 N% ^5 y; X1 [& X# o, a
http://www.geocities.com/CollegePark/lab/1580/apoptosis.html
+ r+ P: b% G J' S* |$ {; K+ E* Examples of programmed cell death * Diagrams
) R' l' ], x1 k+ F5 B4 [$ b: ?& _Introduction to Apoptosis 8 A% j( U9 f H+ ~! p" P
http://www.acs.ucalgary.ca/~browder/apo_intro.html 8 u' a- v# ?- u5 C+ j4 r
* References * Description of apoptosis |